Francesca Pia Vitale performed in numerous concerts and took part in masterclasses with Luciana D’intino, Renato Bruson, Eva Mei, Leo Nucci, Ildar Abdrazakov and Nino Machaidze and enriched her studies under the guidance of Vincenzo Scalera, Michele D'Elia and Umberto Finazzi. She has received praise and acclaim from directors such as Woody Allen, Gilbert Deflo, Grisha Asagaroff, Ulrich Peter and Marina Bianchi and from conductors such as Zubin Mehta, Daniel Oren and Stefano Ranzani. She made her debut on the stage of La Scala playing the role of Giannetta in L’elisir d'amore per i bambini, conducted by Pietro Mianiti and staged by Grischa Asagaroff. Accademia productions in the 2018/19 season at La Scala included the roles of Tonina and Nella in the diptych Prima la musica poi lei parole and Gianni Schicchi, conducted by Ádám Fischer and directed by Woody Allen, and Il Paggio in Rigoletto conducted by Daniel Oren under the direction of Gilbert Deflo. Later in the same season, she performed the role of Giannetta in the La Scala production of L’elisir d’amore, conducted by Michele Gamba and directed by Grischa Asagaroff with scenes and costumes by Tullio Pericoli. She also took part in La Cenerentola per i bambini as Clorinda. She made her debut at the Teatro Lirico in Cagliari in a production of Hänsel und Gretel by E. Humperdinck in the roles of Sandmanchen and Taumanchen. She was due to perform the role of Oscar in Un ballo in maschera in a production at Teatro alla Scala in the 2019/20 season which was subsequently cancelled due to Covid-19.. During the Autumn 2020 season of La Scala she sang the role of Annina in La Traviata under the direction of Zubin Mehta, and on 24 October 2020 she graduated from the Accademia Teatro alla Scala - Biennium 2018/2020.